2-Propoxy-5-(trifluoromethyl)phenylboronic acid
(2-Propoxy-5-(trifluoromethyl)phenyl)boronic acid
CAS: 1162257-29-5
Molecular Formula: C10H12BF3O3
2-Propoxy-5-(trifluoromethyl)phenylboronic acid - Names and Identifiers
2-Propoxy-5-(trifluoromethyl)phenylboronic acid - Physico-chemical Properties
| Molecular Formula | C10H12BF3O3 |
| Molar Mass | 248.01 |
| Storage Condition | Sealed in dry,2-8°C |
| Sensitive | IRRITANT |
| MDL | MFCD16036114 |
2-Propoxy-5-(trifluoromethyl)phenylboronic acid - Introduction
(2-Propoxy-5-(trifluoromethyl)phenyl)boronic is an organoboron compound with the formula C10H11BF3O2. It has the following properties:
1. Appearance: colorless solid
2. solubility: soluble in water and common organic solvents, such as ethanol and dimethylformamide.
3. melting point: about 93-95 degrees Celsius.
(2-Propoxy-5-(trifluoromethyl)phenyl)boronic acid has the following uses:
1. As an important intermediate in organic synthesis, it is often used to introduce phenylboronic acid groups in the synthesis of drugs, pesticides and functional materials.
2. It can be used as a coordination reagent to cooperate with metal catalysts to participate in C- C bond formation reactions, such as Suzuki reaction and Buchwald-Hartwig reaction.
3. It can also be used for the preparation of organic electronic devices, such as the synthesis of fluorescent dyes and the preparation of organic light-emitting diodes.
Preparation method:
(2-Propoxy-5-(trifluoromethyl)phenyl)boronic acid is usually synthesized by the following steps:
1.1,2-dibromoethane and diethyl terephthalate are reacted in the presence of a base to obtain diethyl (2-propoxy) phenylacetate.
2. Reaction of diethyl (2-propoxy) phenylacetic acid with trifluoromethylphenylboronic acid in the presence of a base to give (2-Propoxy-5-(trifluoromethyl)phenyl)boronic acid.
Safety Information:
(2-Propoxy-5-(trifluoromethyl)phenyl)boronic acid has low toxicity, but should be handled with caution. Follow general laboratory safety regulations and wear protective glasses, gloves and laboratory coats during operation. If ingestion or contact with skin, seek medical attention immediately and bring information about the compound.
1. Appearance: colorless solid
2. solubility: soluble in water and common organic solvents, such as ethanol and dimethylformamide.
3. melting point: about 93-95 degrees Celsius.
(2-Propoxy-5-(trifluoromethyl)phenyl)boronic acid has the following uses:
1. As an important intermediate in organic synthesis, it is often used to introduce phenylboronic acid groups in the synthesis of drugs, pesticides and functional materials.
2. It can be used as a coordination reagent to cooperate with metal catalysts to participate in C- C bond formation reactions, such as Suzuki reaction and Buchwald-Hartwig reaction.
3. It can also be used for the preparation of organic electronic devices, such as the synthesis of fluorescent dyes and the preparation of organic light-emitting diodes.
Preparation method:
(2-Propoxy-5-(trifluoromethyl)phenyl)boronic acid is usually synthesized by the following steps:
1.1,2-dibromoethane and diethyl terephthalate are reacted in the presence of a base to obtain diethyl (2-propoxy) phenylacetate.
2. Reaction of diethyl (2-propoxy) phenylacetic acid with trifluoromethylphenylboronic acid in the presence of a base to give (2-Propoxy-5-(trifluoromethyl)phenyl)boronic acid.
Safety Information:
(2-Propoxy-5-(trifluoromethyl)phenyl)boronic acid has low toxicity, but should be handled with caution. Follow general laboratory safety regulations and wear protective glasses, gloves and laboratory coats during operation. If ingestion or contact with skin, seek medical attention immediately and bring information about the compound.
Last Update：2024-04-09 02:00:57
